Dithiane deprotection
WebThe 1,3-dithiane-based dM-Dmoc group was studied for the protection of amino groups. Protection was achieved under mild condi-tions for aliphatic amines, and under highly reactive conditions for the less reactive arylamines. Moderate to excellent yields were obtained. Deprotection was performed by oxidation followed by treating with a weak base. WebSep 1, 2003 · solid-state conditions for the deprotection of 2-(3-nitrophenyl)-1,3-dithiane to afford 3-nitro- benzaldehyde in 95% yield. It should also be noted that no exotherm or other safety problems were
Dithiane deprotection
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WebA number of 1,3-dithianes have been efficiently converted into the parent carbonyl compounds in good yields by treatment with 1.5 equiv. of 2,3-dichloro-5,6-dicyano-p … Web238000010511 deprotection reaction Methods 0.000 description 19; 238000010898 silica gel chromatography Methods 0.000 description 19; ... CXWGKAYMVASWDQ-UHFFFAOYSA-N Dithiane Chemical compound C1CCSSC1 CXWGKAYMVASWDQ-UHFFFAOYSA-N 0.000 description 2; 230000035693 Fab Effects 0.000 description 2;
WebA number of 1,3-dithianes have been efficiently converted into the parent carbonyl compounds in good yields by treatment with 1.5 equiv. of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) in MeCN–H 2 O (9:1).The reactions of 2-aryl-substituted 1,3-dithianes bearing electron-donating groups on the benzene ring with DDQ afforded thioesters … WebDec 11, 2007 · Aerobic solid state deprotection of 1,3-dithianes and 1,3-dithiolanes of aromatic and aliphatic aldehydes and ketones has been performed in excellent yields by …
WebDec 11, 2007 · Aerobic solid state deprotection of 1,3-dithianes and 1,3-dithiolanes of aromatic and aliphatic aldehydes and ketones has been performed in excellent yields by Cu(NO3)2·2.5H2O in the presence of ... WebOxidative deprotection of 1,3-dithiane group using NaClO 2 and NaH 2 PO 4 in aqueous methanol. / Ichige, Takahiro; Miyake, Annu; Kanoh, Naoki et al. In: Synlett, No. 10, 09.08.2004, p. 1686-1690. Research output: Contribution to journal › Article › peer-review
WebFeb 7, 2008 · Preliminary attempts at using a dithiane based strategy for the assembly of the dihydroxycarbonyl moiety were unsuccessful. Therefore, a different procedure involving the utilization of the nitrocompound chemistry was pursued. ... that upon acidification undergoes succesive THP deprotection, Nef reaction and ketalization affording …
WebDeprotection. A simple protocol for the deprotection of 1,3-dithianes and 1,3-dithiolanes showed tolerance for a number of phenol and amino protecting groups using 30% aqueous hydrogen peroxide activated by … scale on the graphWebDeprotection of thioketals and thioacetals with mercury (II) nitrate trihydrate proceeds readily under solid-phase conditions. Initially, we decided to explore the role of both the … scale on tree trunksWebDec 19, 2012 · An effective deprotection methodology of dioxolanes was developed, affording moderate to excellent yield via a LTMP-promoted reaction in THF, which displays admirable chemoselectivity in the presence of dimethylketal, 1,3-dioxane, 1,3-dithiane, or other acid-sensitive protective groups. saxenda weight loss insurance coverageWebJan 1, 2014 · 12. H g X 2 + has a high affintity to thiols and other sulfur functional groups, and therefore H g C l X 2 forms a Lewis acid-base adduct with the dithiane. The cyclic sulfonium cation undergoes ring opening, … saxenda weight loss medicaid paidWebMay 27, 2002 · Removal of 1,3-dithiane is, however, relatively difficult and often requires harsh conditions. 7., 7.(a), 7.(b), 7.(c) Because cleavage of the 1,3-dithiane group is usually performed in the late synthetic stage, 8 a new mild deprotection condition will … scale on wheelsWebFeb 18, 2024 · Reactions for the deprotection of carbonyl derivatives have been of considerable interest to the scientific community. In recent years efforts have been made to develop mild, experimentally simple, and environmentally friendly methods. This update to previous research provides a comprehensive review of processes for the deprotection of ... scale on topographic mapWebThe formation as well as deprotection is promoted by suitable Lewis acids. The thioacetals are markedly stable under deketalation conditions, thus paving way for selective operations at two different centers. When conjugated ketones are involved, the ketal formation (as well as deprotection) proceeds with double bond migration. saxenda weight loss injections reviews