WebCancer-causing mutations often arise from inappropriate DNA repair, yet acute exposure to DNA damage is widely used to treat cancer. The challenge remains in how to specifically induce excessive DNA damage in cancer cells while minimizing the undesirable effects of genomic instability in noncancerous cells. One approach is the acute exposure to … WebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest …
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WebChaudhari S, Ware AP, Jayaram P, Gorthi SP, El-Khamisy SF, Satyamoorthy K. Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability . WebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations.
WebSherif M. Shawky, Ahmed A. Abo-AlHassan, Holger Lill, Dirk Bald, Sherif F.EL-Khamisy, El-Zeiny M. Ebeid. Objectives: Development of a novel method for loading drugs into spherical mesoporous silicate nanoparticles (MSNs), and further modification for the loaded MSNs to produce smart drug delivery system. WebOct 28, 2010 · Zhihong Zeng, Felipe Cortés-Ledesma, 1 Sherif F. El Khamisy, 2 and Keith W. Caldecott 3 Zhihong Zeng From the Genome Damage and Stability Centre, Science Park Road, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom
WebThe importance of this mode of catalysis is highlighted by the human genetic, neurological disease SCAN1, which is associated with mutations in TDP1 and defects in the repair of Top1-SSBs induced by the Top1 poison camptothecin (CPT), hydrogen peroxide or ionizing radiation (El-Khamisy et al, 2005; Interthal et al, 2005a; Katyal et al, 2007; Takashima et al, … WebJan 29, 2024 · Ringaile Zaksauskaite, 1 Ruth C Thomas, 1, 2 Freek van Eeden, 1, 2, * and Sherif F. El-Khamisy 1, 3, * Author information Article notes ... El-Khamisy S. F., TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Res ...
WebFeb 28, 2024 · Correspondence to Sherif F. El-Khamisy. Ethics declarations. Conflict of interest. The authors declare no competing/ conflicting interests. Additional information. Publisher's Note. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
WebSherif El-khamisy Co-Founder, Healthy Lifespan Institute, University of Sheffield & Director Institute of Cancer Therapeutics, University of Bradford 1y Report this post ... my recovery fujitsu downloadWebJul 31, 2024 · A renowned expert on DNA has been appointed as the new Director of the University of Bradford’s Institute of Cancer Therapeutics (ICT) from August 3.. Professor … the seven sons of soulWebProfessor Sherif El-Khamisy Director/Associate Dean(R & I) Faculty/Dept/School: School of Pharmacy and Medical Sciences (Faculty of ... Naylor KL;Bulgakova NA;F El-Khamisy … my recovery journalWebSherif F El-Khamisy 1 , Edgar Hartsuiker, Keith W Caldecott. Affiliation 1 Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton, UK. … my recovery gmailWebSep 1, 2012 · Finally, mice lacking both Tdp1 and Tdp2 exhibit greater sensitivity to Top1 poisons than do mice lacking Tdp1 alone, further suggesting that Tdp2 contributes to the … the seven spirits in revelationWebJun 2, 2024 · The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration. … the seven sisters series kindleWebSherif F El-Khamisy 1 Affiliation 1 School of Biosciences, The Healthy Lifespan and Neuroscience Institutes, Firth Court, University ... University of Bradford, Bradford, UK. … the seven sons movie